AnimalBiome: Gut Maintenance Plus

Reduces Diarrhea Caused by Antibiotics, C. difficile and E. coli

Powerful blend of prebiotics and probiotics designed to stop occasional diarrhea flare-ups.

Gut Maintenance Plus Active Ingredients:

  • Saccharomyces boulardii (S. boulardii)  
  • MannanOligoSaccharides (MOS)
  • PreForPro(TM)

Saccharomyces boulardii (S. boulardii pronounced "ess-boo-lar-dee") is a yeast-based probiotic first described in 1920 and the subject of over 250 peer-reviewed articles. S. boulardii has been shown to resolve diarrhea caused by antibiotics. (Czeruka et al.). More recently, researchers found that in dogs with chronic enteropathy, adding S. boulardii to the standard treatment resolved diarrhea within 5 days. (D'Angleo et al.)

Because probiotics like S. boulardii do better when accompanied by the food they like to eat (prebiotics) Gut Maintenance Plus also contains MOS. MOS is derived from the cell wall of Saccharomyces cerevisiae (commonly known as brewer’s yeast) and has been shown to improve intestinal health and work synergistically with S. boulardii. (Spring et al.).

PreforPro is a prebiotic bacteriophage cocktail that prepares the gut to ensure healthy probiotic bacteria have room to flourish. Developed and patented by Deerland Enzymes, more than 20 studies have been performed to confirm the safety and efficacy of PreforPro in humans.

AnimalBiome has been recommending these ingredients to our customers since 2018 with very positive results and created this proprietary blend to make it easier for our customers to get all three ingredients in one bottle at doses more appropriate for cats and dogs.

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A Healthy Pet Starts With A Healthy Gut

Research has shown that a balanced gut microbiome (the digestive system and how it handles food for nutrition and energy) is essential to overall health and longevity. When a pet’s microbiome is unbalanced, diarrhea, skin, immune system, and weight problems occur, and managing unpleasant symptoms can affect quality of life for pets (and pet parents).

Testing your pet’s microbiome provides insight into their gut health status, and our first-of-its-kind fecal microbiota transplant capsules help supplement and restore your pet’s microbiome while relieving troublesome symptoms.

Our Process: Assess, Restore, and Maintain

Our Microbiome Tests and Supplements can be used separately, or combined, to help improve your pet’s gut and overall health. Here’s how they work together:


We use genetic sequencing to detect bacterial imbalances, identify which groups may be causing problems, and tell you how to fix it. Then, we provide a detailed test report with personalized diet, lifestyle, or supplement recommendations to improve pet gut health.


When a bacterial imbalance is detected, use our Gut Restore Supplement along with our diet and other supplement recommendations to restore balance in the gut. Our science-backed supplements, designed specifically for cats or dogs, introduce an entire community of beneficial bacteria to the gut microbiome.


A pet’s gut microbiome is an ever-changing ecosystem of bacteria that is impacted by factors, including diet, medications (like antibiotics), and the environment. Maintain a healthy gut by retesting the microbiome regularly and using supplements if indicated.

Frequently Asked Questions

Is this supplement right for my pet?

This supplement is intended to help rebalance and support a healthy microbiome. Specifically, it helps reduce populations of Clostridium and E coli bacteria, both of which can contribute to health problems when they are present in large numbers. Prior to using the supplement, we recommend testing your pet’s microbiome with a Gut Health Test.  

This supplement is not recommended for pets who experience constipation.

Seek veterinary help if your pet's diarrhea is accompanied by lethargy, loss of appetite, bloating, apparent abdominal pain, repeated vomiting, large amounts of blood or the ingestion of poison or if the diarrhea lasts more than three weeks even if it varies in intensity from day to day.    

How long should my pet stay on this supplement?

This supplement is intended to be used for periods of up to 2 months.

Can I continue my pet’s other medications?

This supplement can be given with any other medications and/or supplements. While we’ve seen many pets benefit from this supplement, we always recommend checking with your pet’s veterinarian before changing their regimen.

Are there any risks associated with this supplement?

While this supplement is intended specifically for pets with microbiome-related health issues, in rare cases, it can cause symptoms to worsen. Constipation is the most common side effect. If your pet’s symptoms worsen after beginning this supplement, stop giving the supplement until their condition stabilizes.

Please contact us with any questions or concerns: